Tag: Gene therapy

ECONOGAL > Gene therapy

Pandemic Book Review

Posted on by Econogal

Book cover of Pandemic by Robin CookPandemic by Robin Cook opened my eyes to the dark side of the biotech world. Protagonist Dr. Jack Stapleton, a New York City medical examiner, fears an influenza virus is the cause of a sudden death on the subway of a young woman. He is wrong about the cause of death. But his instincts are on target.

Stapleton is married to his boss, Dr. Laurie Montgomery. There is quite a bit of tension in their relationship. Both at home and at the office, tempers flare. Jack begins to shut his wife out. In the end this puts his life in jeopardy.

Organ Transplant

At the center of the plot is a young heart transplant patient. The reader watches her race along the subway platform in order to catch a train. She makes it. Her heart beat returns to normal. Then death strikes. The first symptom is a chill followed by breathing difficulties. She dies before reaching her destination.

The autopsy reveals a heart transplant, with the heart in fantastic shape. But the lungs are filled with pus. Stapleton hypothesizes death by virus, but pathology tests are inconclusive. To make things worse, the patient is a Jane Doe. Stapleton, unwilling to face problems on the home front, buries his troubles in his quest to identify both the woman and her cause of death.

Characters

This was the first Robin Cook novel I had read, so all the characters were new to me. But to existing fans there are both recurring and fresh faces in the story. For a new reader, the returning characters were not as richly developed as the newbies. Only the stress of living with a special needs child defines the relationship of Stapleton and Montgomery.

CRISPR/Cas9

The acronym CRISPR stands for clustered regularly interspaced short palindromic repeats. Cas9 is a protein. A better explanation of this genetic breakthrough than I can give can be found in this video from University of California-Berkeley

Cook uses the novel Pandemic to introduce the promises of CRISPR/Cas9 as well as the serious consequences of the misuse of technology. The possibilities remain to be seen. But, birth defects such as Cystic Fibrosis and Duchenne Muscular Dystrophy are among the targets for this technology.

Mirroring Trends

I found it unsurprising that a billionaire capitalist was the villain of the story. Nor was I surprised that the communist leaning millennial son saves the day for both Stapleton and the world. Yet, the virus was concocted by the son. Definitely some mixed message in this book.

Cook even throws in some comments from the son of how divisive America is as compared to a more unified younger Chinese population:

In dialogue, the young man states: “We Chinese university-age generation are all on the same page, whether we are in school in Wuhan, or Canberra, or Paris, or Boston. We are of the same mind-set to truly make China great again, pardon the hackneyed phrase. Whereas here in the USA there is depressing divisiveness and a kind of anti-immigrant neotribalism that is getting progressively worse, in China we millennials are coming together.” (Cook, 2018, page 372)

My economic background understands mixed economies. Capitalist societies have some socialism within the market. The same holds true for the other “isms.” I tend to cringe when I read praise for Communism and Socialism. But we have a generation raised after the fall of the Berlin Wall. The fears of yesterday disappear as time marches forward.

Pandemic is worth reading. Cook brings attention to a rapidly changing world. Yet, pausing to think about the consequences of the change has merit. Let me know what you think of this novel.
For those of you interested in learning more about gene therapy the following website is informative:

https://www.neb.com/tools-and-resources/feature-articles/crispr-cas9-and-targeted-genome-editing-a-new-era-in-molecular-biology

February 2018 Wrap Up

Posted on by Econogal

February 2018 was a short month! I am a few hours late posting this but that is what happens when you only have twenty-eight days. I really needed a leap year! In our part of the world we had a month with little moisture. Just a skiff of snow one morning which began dripping off the roof before mid-morning, I actually hooked up the hoses to water the trees. We had one day of high winds accompanied by fire warnings. This is quite a contrast to those of you who are water-logged.

My New Year’s resolutions are holding up. I added to my skills by learning to prune grapevines. I am a bit worried that I cut them back too far, but all the You Tube videos I watched warned I would feel this way. You Tube is a great tool for visual learners.

February 2018 Celebrations

February 2018 hosted many celebrations including a baby shower, a birthday and an anniversary. The baby shower marked the last time I indulged in any sweets. Ash Wednesday also occurred on Valentine’s Day and in observation of the Lenten season I am abstaining from sugar. This was prompted by my first book review of the month, The Case Against Sugar.

This time of year is usually so cold I limit myself to indoor activities. But February 2018 acted like a yo-yo. Our area bounced back and forth between days which remained below freezing and days that reached the seventy degree mark. As a result, some of my time was spent prepping the garden. Garlic and onions planted last fall are poking through along with the earliest of the spring bulbs. I may have erred on the early side, but rutabaga and potatoes were also planted. Some late snows would be welcome.

On the February 2018 days that were too cold to work outside, the indoor activities included starting a new acrylic painting. Unfortunately, my schedule keeps me from taking classes so I am taking the self-taught approach. In this case I am using a library book. This is my first attempt at painting a scene with water. So far, Creative Acrylic Painting Techniques published by North Light Books has been helpful. The photo below is after three days of painting.

Wild Markets

My reading this month included quite a few articles from the Wall Street Journal during the market sell-off. February 2018 marked the end of a very long run of gains. The volatility was not unlike that of the markets a decade ago. Although markets are unpredictable, I personally don’t feel the doom and gloom I experienced in late 2007 and all of 2008. However, I am keeping a close watch. Unlike the totally insane housing bubble, the markets rise over the past few years has a backbone. A correction is certainly due and perhaps even overdue. But unlike ten years ago, I see real cause for growth.

Technology is changing at a rapid pace and in more than one area. Computers and communications may be a driving force, but the health field is also undergoing great changes. Much of this growth stems from the unraveling of DNA. Much research is occurring. In some cases genetic diseases can be treated. However, the cost is tremendous as you can read here regarding gene therapy.

Even though I am optimistic about economic growth, there are some concerns. The greatest from an economic standpoint is the economic debt of nations. Two articles worth reading are from Statista and Global Finance. Countries with external debt carry a risk. In my opinion, some risk is acceptable. Most of the viable national economies operate with external debt. The concern is reaching the point where the debt is so great, the debt payments cannot be met. This tipping point is unknown. But, as in the case of Venezuela, which you can read about here, once a nation is insolvent things go downhill fast. For those residing in the United States, an up to the second accounting is given by the Debt Clock. The picture is not pretty.

Acrylic painting of water and grasses
Third Day of Progress

Quick Thanks

A quick thanks to Moe for sharing reading lists last month. It can be hard to comment first. I appreciate the involvement in the readership community. Please feel free to share what book you have on your bedside table.
Currently, I am reading New York Station so look for it in a review later this month. I also have a stack of gardening books. February 2018 was a short month so my reading fell behind. What else should I be reading?